Explore comprehensive data, application notes, and posters highlighting the G4 Sequencing Platform’s performance and capabilities.


RNA Sequencing

RNA sequencing (RNA-Seq) is used to assess differential gene expression profiles, detect novel transcripts, and characterize new splice variants or cell types. Explore how the reimagined chemistry and advanced engineering of the G4 can improve your RNA sequencing.

Single Cell RNA Sequencing

Single cell RNA sequencing (scRNA-Seq) has revolutionized basic and translational research in immunology, developmental biology and cancer by enabling the resolution of distinct cell populations within heterogeneous samples. Explore how the G4 can seamlessly integrate into your scRNA-Seq workflow and accelerate your results without sacrificing accuracy.

Whole Exome Sequencing

Whole exome sequencing (WES) is a next-generation sequencing method used to discover and assess genetic variations linked to rare or complex diseases. Learn how the G4 provides excellent variant-calling accuracy and unmatched speed and versatility to labs performing WES.

Whole Genome Sequencing

Whole genome sequencing (WGS) is the process for analyzing the complete genetic makeup of an organism. Learn more about the suitability of the G4 for human whole genome sequencing in the WGS technical report.


Introducing the G4 Sequencing Platform | The World's Most Powerful Benchtop Sequencer
Delivering Fast, Flexible Next Generation Sequencing Through Innovations in Chemistry and Engineering
Advancing Speed, Versatility, and Accuracy in Next-Generation Sequencing | PMWC Conference 2022

Posters & Publications

AGBT 2022

Bacterial Whole Genome Assembly and Microbial Community Analysis with the G4

by JGI (Christopher G. Daum et al.)

AGBT 2022

Singular Genomics’ G4 Platform Technology Assessment

by TGEN (Candice L. Wilke et al.)

AGBT 2022

Training and Validation of an Accelerated DeepVariant Model for Germline Exome Analysis on the G4

by Singular Genomics (Kenneth Gouin III et al.)

AGBT 2022

Max Read: A Novel High-Throughput Short-Read Format for the G4 Sequencing Platform

By Singular Genomics (Niek van Wietmarschen et al.)

AGBT 2022

Evaluation of the Singular Genomics G4 Sequencing Platform with Resolution ctDx Assays on Cell-Free DNA

by Resolution Biosciences (Carolyn Hutcheon et al.)

AGBT 2022

HD-Seq: A Novel Method for High Accuracy Sequencing

by Singular Genomics (Sabrina Shore et al.)

bioRxiv, 2022

XR-Seq: Reconstruction of Full-Length scFv Libraries with the Extended Range Targeted Sequencing Method

(Christopher Wei et al.)

Innovation with Intention

Featuring novel, high-performance chemistry and advanced engineering, the G4 Sequencing Platform has been optimized to deliver speed, power, unprecedented flexibility, and accuracy.